Advanced models for pre-clinical translation sciences.
Proof of Concept Research
- Consultation on the pre-clinical laboratory’s capabilities and model design.
- Pilot experiments needed to generate preliminary data for a grant proposal or assess feasibility of an idea. (Subject to funding availability)
Research Seeking Funding
- Collaborative grant proposal and project development including consultation with our pre-clinical modeling experts.
- We will help you with your pre-clinical study’s experimental design and implementation (with budgeted effort).
Funded Research
- Implement and execute research projects that are funded by industry, grants, or other means
- We have the capabilities and expertise necessary to execute pre-clinical models for your funded research.
The Weil Institute Pre-Clinical Critical Care Laboratory produces best-in-class, high-fidelity models of multisystem disease and injury including—but not limited to— sepsis, cardiac arrest, hemorrhage control, ARDS, and traumatic brain injury.
Our lab is equipped with a state-of-the-art high resolution physiologic and metabolic monitoring and analytic equipment providing for unique “physiomic” monitoring, tissue banking and analysis for pre-clinical research. Our models are available for integrated projects ranging from exploring the basic pathophysiology of critical illness and injury to developing new diagnostics, therapeutics, devices, and digital health solutions ready for clinical testing in critical care.
Together, we can…
- Support your project with the expertise of our highly qualified and trained personnel
- Provide advice and assistance with all aspects of protocol development and IACUC submission (writing, statistical procedures, power analysis, etc.)
- Provide technical and hands-on assistance with experimental procedures (Anesthesia, surgery, data collection and storing, blood and tissue sampling and recovery) and statistical analysis
- Assist with regulatory requirements
- Assist with data analysis and reporting
- Provide technical training and educational sessions.
"The Pre-Clinical Lab is a critical asset for translational researchers like me. Our models of critical illness faithfully recapitulate human disease: physiologically, radiographically, immunologically, and histologically. We are truly fortunate to have the expertise and professionalism of our Pre-Clinical Lab team."
- We have a proven track record of success working with large animals to model critical care diseases
- Research results from our lab have been published in high impact journals such as the Journal of Neurotrauma, Resuscitation, Journal of Trauma, and the Journal of Critical Care
- We collaborate extensively across medical & engineering disciplines, both locally and nationally
- Several of our team members have received federal & institutional funding
- Our team has a wealth of expertise in all aspects of project development, navigation of regulatory issues, and execution of experimental design
- We have extensive experience working with and training students and health care professionals
For further information, questions or to request a meeting, contact Hakam Tiba, MD or Brendan McCracken, MS.
