Enhancing the Michigan Medicine Research Community
Clinical and epidemiological studies demonstrate a strong link between diseases of the heart and the brain. Many within the U-M research community are at the forefront of research examining the connection between these two critical organs.
The Stanley and Judith Frankel Institute for Heart and Brain Health (Frankel IHBH) brings together current and new U-M researchers to unravel the biological mechanisms that the heart and brain have in common, as well as how these organs signal to each other and impact clinical outcomes.
Discovering the root causes of heart and brain disease, determining how these organs communicate with each other, and developing the treatments of tomorrow.
Our discoveries will propel life-changing new approaches to the prevention and treatment of heart and brain diseases.
Collaboration and engagement with the clinical and scientific community at the University of Michigan is essential to the success of Frankel IHBH, we are actively developing initiatives and events to facilitate such interactions for our members.
The American Heart Association funds scientists at University of Michigan, Northwestern University and University of Pittsburgh for studies focused on closing knowledge gaps about inflammation’s role in cardiac and brain dysfunction.
Skeletal muscle plasticity and remodeling are critical for adapting tissue function to use, disuse, and regeneration. The aim of this study was to identify genes and molecular pathways that regulate the transition from atrophy to compensatory hypertrophy or recovery from injury. Here, we have used a mouse model of hindlimb unloading and reloading, which causes skeletal muscle atrophy, and compensatory regeneration and hypertrophy, respectively.
