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Supporting researchers of all stripes
Large or small, funded or exploratory, your project fits our pipeline.
Proposal Development
Consulting and support services for multi-disciplinary teams pursuing research awards
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Pre-Clinical Critical Care Laboratory
Producing best-in-class, high-fidelity models of multisystem disease and injury such as sepsis and ARDS
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Clinical Research
Assisting investigators with patient recruitment, IRB submissions, and data collection/processing
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Data Science
Data modeling, analysis, and analytics used to develop clinical decision support tools
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Product Commercialization
Strategically collaborating with PIs and teams to propel products to commercial viability
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If you are a Weil Institute member working on a research project related to critical care, you're in the right place! Your goal might be to polish a proposal to perfection. Or maybe you need data from a preclinical model to assess feasibility for a grant. No matter what you’re looking for, the Weil Institute can provide the guidance and resources you need to propel your research.
Through our Proposal Development team and our renowned Grand Challenge program, we've brought in over $50M in funding for our members.
Keep scrolling to see featured research projects as well as a list of every funded project we have supported since the very beginning.
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Elevating Traumatic Brain Injury Research with Cutting-Edge Microscopy and Clinically Relevant Monitoring | $1,205,722 | February 2024 | 1 year | Office of Naval Research | J. Wider, T. Sanderson, H. Tiba | ||
| Point-of-care micro-gas chromatography device for diagnosis and monitoring of acute respiratory distress syndrome using exhaled breath signatures | $4,902,534 | January 2024 | 4 years | NIH / NHLBI | X. Fan, M. Sjoding, K. Ward |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| A Tropical Geometry-Based Fuzzy Neural Network Approach to Diuretic Management after Congenital Cardiac Surgery | $350,000 | December 2023 | 3 years | Gerber Foundation | D. Ehrmann | ||
| Sepsis RM1 Pilot Study and Grant Preparation | $141,443 | 8/15/2023 | 1 year | U-M OVPR Bold Challenges Accelerate Program | R. Dickson | ||
| A Fuzzy Neural Network Physiologic Closed Loop Control System for Diuretic Management after Congenital Cardiac Surgery | $47,005 | 8/2023 | 1 year | U-M Frankel Cardiovascular Center Innovation Challenge | D. Ehrmann; K. Najarian | ||
| Detection of Exhaled Breath Markers After Traumatic Brain Injury using Point of Care Gas Chromatography | $80,000 | 7/26/2023 | 2 years | U-M Medical School Office of Research/Research Scouts | H. Tiba | ||
| Modeling the relationship between automatic optic nerve sheath diameter measurements from computed tomography scans and intracranial pressure in traumatic brain injury patients | $104,772 | 7/1/23 | 1 year | Massey TBI Grand Challenge | E. Stein; K. Najarian; E. Wittrup; C. Williamson | ||
| Clinical Development of LUCID: A Therapeutic Device for Non-Invasive Mitochondria Modulation in Adult TBI Patients (Follow-on to 2022 Grant) | $154,219 | $163,014 | 7/1/23 | 1 year | Massey TBI Grand Challenge | F. Schmitzberger; T. Sanderson | |
| Glycemic Variability Following Traumatic Brain Injury: Utilizing a Continuous Glucose Monitor in the Golden Hours to Improve Patient Outcomes | $149,166 | 7/1/23 | 1 year | Massey TBI Grand Challenge | K. Seagly; N. Haas | ||
| Development of an Ultrasound-based Flow-pressure Index for the Assessment of Cerebral Autoregulation | $142,980 | 7/1/23 | 1 year | Massey TBI Grand Challenge | J. Brian Fowlkes | ||
| Clinical and pre-clinical development of LUCID for reducing brain injury following pediatric cardiac bypass | $97,158 | 6/1/23 | 1 year | Kahn Pediatric Critical Care Grand Challenge | N. Sznycer-Taub; T. Sanderson | ||
| Vascular Arterial Tone Monitoring System (VATMOS) for Managing and Treating Hemodynamic Instability in Pediatric Critical Care | $82,012 | 6/1/23 | 1 year | Kahn Pediatric Critical Care Grand Challenge | K. Oldham; R. Daniels | ||
| Expediting Bedside use of a Novel Microfluidics-Based Platform for the Identification of Sub phenotypes in Critically Ill Pediatric Patients | $100,000 | 6/1/23 | 1 year | Kahn Pediatric Critical Care Grand Challenge | H. Flori; M. Dahmer; K. Kurabayashi | ||
| Evaluating Lung Injury through Exhaled Volatile compounds and redox potential to predict ARDS and its Trajectory in childrEn (ELEVATE) | $99,646 | 6/1/23 | 1 year | Kahn Pediatric Critical Care Grand Challenge | R. Barbaro; R. Daniels; X. Fan | ||
| Automated Image Processing Systems Capable of Mitigating Uncertainty and Normal Biological Variations: An Application to Acute Respiratory Distress Syndrome (ARDS) | $238,315 | 5/1/23 | 2 years | MICHR | N. Farzaneh | ||
| CD98hc-mediated delivery of an ultrapotent TrkB agonist antibody for neuroprotection and improved cognitive recovery after traumatic brain injury (follow-on to 2021 grant) | $98,717 | $755,679 | 9/30/23 expected | 3 years | DoD | C. Greineder, P. Tessier | |
| Great Lakes Clinical Center for the ARDS, Pneumonia, and Sepsis Phenotyping Consortium | $3,305,745 | 5/1/23 | 6 years | NIH | R. Hyzy, H. Prescott, R. Dickson | ||
| NIH T-32 Acute and Critical Care Engineering (ACCE) Training Program | $1,268,771 | 4/20/23 | 5 years | NIH | K. Oldham, K. Kurabayashi, K. Ward |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Accuracy of Continuous Glucose Monitor in DKA (ACID) | $25,000 | 12/14/22 | 1 year | SAEM | N. Haas | ||
| Elucidating Pediatric Sepsis by Defining Comprehensive Signatures for Diagnosis and Outcome | $3,333,188 | 11/1/22 | 5 years | NIH | P. Mahajan | ||
| High Performance Wearable Body Odor Sensor Arrays for Disease Detection and Monitoring | $5,688,584 | 8/2/22 | 5 years | NIH | S. Fan, J. Gudjonsson, K. Gunnerson, Y. Huang, P. Mahajan | ||
| Dose-Response Effect of of Intranasal Insulin Using Functional MRI | $142,939 | 7/1/22 | 1 year | Massey TBI Grand Challenge | F. Schmitzberger | ||
| Evaluation of Immunomodulatory Device for Early Treatment of TBI | $185,205 | 7/1/22 | 1 year | Massey TBI Grand Challenge | D. Humes | ||
| Regulatory Testing for LUCID-TTM: Dual Therapeutic Device | $154,219 | 7/1/22 | 1 year | Massey TBI Grand Challenge | T. Sanderson | ||
| Continuous Cerebral Blood Flow Monitoring using Augment ICP Sensor | $118,852 | 7/1/22 | 1 year | Massey TBI Grand Challenge | K. Oldham, H. Tiba | ||
| Michigan Algorithm for Acute Evaluation of TBI (Continuation of 2021 grant) | $131,093 | $1,499,062 | 7/1/22 | 1 year | Massey TBI Grand Challenge | K. Seagly | |
| Retinal Oximeter for Detection of Brain Tissue Hypoxia in TBI | $165,639 | 7/1/22 | 1 year | Massey TBI Grand Challenge | J. Myers, Y. Paulus | ||
| The Role of the Gut Microbiome in TBI | $164,845 | 7/1/22 | 1 year | Massey TBI Grand Challenge | R. Dickson, H. Tiba | ||
| Improving Cardiovascular Disease Detection with a Novel Multi-label Classifier for Electrocardiograms: Capturing Label Uncertainty and Complex Hierarchical Relationships between Output Classes | $30,000 | 6/28/22 | 1 year | U-M MIDAS | N. Farzaneh | ||
| TRANSatlantic Cardiac arrEst Neuroprotection aDvancement (TRANSCEND) Network Preclinical Registry | $50,000 | 6/10/22 | 1 year | Laerdol Foundation | R. Neumar | ||
| Development and Validation of a Clinically Relevant Swine Model of Neurologic Injury After Cardiac Arrest to Translate Neuroprotective | $1,154,289 | 5/6/22 | 3 years | NIH | C. Hsu, F. Korley | ||
| Robust Neuroprotection with Noninvasive Near Infrared Light: Translational Development of a Treatment for TBI | $1,459,040 | 5/4/22 | 3 years | Department of Defense | J. Wider, T Sanderson | ||
| Biomarker-Guided Brain CT Imaging in Traumatic Brain Injury | $1,483,462 | 5/4/22 | 3 years | Department of Defense | F. Korley | ||
| A Microfluidics Device for the Measurement of Traumatic Brain Injury Biomarkers at the Point of Care | $1,499,505 | 5/4/22 | 3 years | Department of Defense | F. Korley | ||
| EMMETT (Environment for Model Monitoring, Evaluation and Timely Tuning): A Health IT Tool for Clinical Model Surveillance | $105,707 | 3/22/22 | 1 year | U-M FFMI | S. Ansari | Emerging Product | |
| The Application of Artificial Intelligence, Bedside Monitoring, and Patient Reported Outcomes to Improve Patient Safety and Symptom Relief after Paracentesis | $450,000 | 2/14/22 | 3 years | American College of Gastroenterology | N. Mazumder |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Implementation of an All-Cause Deterioration Model for Adult Inpatients | $199,268 | 8/11/21 | 2 years | The Doctor's Company | S. Ansari | ||
| Prediction of Heart Failure Onset using Multimodal Data Analysis, Deep Learning and Commercial Wearables | $848,513 | 8/8/21 | 5 years | NIH | S. Ansari | ||
| Regulatory Testing for LUCID-TTM: A Dual Therapeutic Device for Non-Invasive Mitochondrial Modulation & Targeted Temperature Management in TBI Patients | $168,948 | $40,000 | 7/1/21 | 1 year | Massey TBI Grand Challenge | T. Sanderson | |
| A BBB Shuttle-Assisted Insulin Receptor Anti-Body for Neuroprotection in TBIm | $98,717 | 7/1/21 | 1 year | Massey TBI Grand Challenge | C. Greineder | ||
| The Michigan Algorithm for Acute Evaluation of TBI | $149,500 | $131,093 | 7/1/21 | 1 year | Massey TBI Grand Challenge | F. Korley, K. Seagly | |
| Impact of Mask Application on Aerosol Generation During CPR in a Swine Cardiac Arrest Model | $78,205 | 6/23/21 | 1 year | Zoll Foundation | C. Hsu | ||
| Hemodynamic Benefits of Aortic Balloon Occlusion During Left Ventricular Assist Device (Impella) CPR | $294,865 | 6/4/21 | 1 year | Abiomed Heart Recovery | H. Tiba | Licensed |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| COVID-19 Detection through scent analysis with a compact GC device | $1,960,142 | 12/21/20 | 2 years | NIH | S. Fan, K. Ward | Emerging Product | |
| Immersive Virtual Reality Environment for Training Acute Care Teams (iREACT) | $200,000 | 12/14/20 | 1 year | The Doctor's Company | M. Cole | ||
| Trans-Ocular Bioimpedance: Seeing the Brain through the Eyes (TOBI) | $153,121 | 9/15/20 | 1 year | Massey TBI Grand Challenge | H. Tiba | Licensed | |
| Therapeutic Enhancement of Mitochondrial Function by Intranasal Mito-AntimiR in TBI | $135,109 | $80,000 | 9/15/20 | 1 year | Massey TBI Grand Challenge | T. Sanderson J. Wider | Licensed |
| Continuous and Point of Care (POC) Reduction-Oxidation (Redox) Monitor for Diagnostic and Therapeutic Use in Traumatic Brain Injury | $75,445 | 9/15/20 | 1 year | Massey TBI Grand Challenge | R. Daniels | Emerging Product | |
| Point-of-Care Microfluidic Device for High Frequency and Real-Time Measurement of Biofluid Biomarkers | $183,128 | $1,499,505 | 9/15/20 | 1 year | Massey TBI Grand Challenge | M. Burns F. Korley | |
| Improved Real-time Surveillance of COVID-19 Patients' Electronic Health Records Using Transfer Learning and Ordinal Regression | $29,725 | 5/13/20 | 7 months | U-M MIDAS PODS | C. Gillies | ||
| Development of Exhaled Breath Signatures for COVID-19 | $30,000 | 4/21/20 | 3 months | U-M COVID Response Innovation Grant | S. Fan, K. Ward | ||
| Computer Vision Technologies for Rapid Detection of the Acute Respiratory Distress Syndrome | $546,000 | 3/26/20 | 1.5 years | Department of Defense | M. Sjoding |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Probabilistic Modeling of Missing Data to Improve Predictions Using Metabolomics Data | $90,000 | 11/15/19 | 1.5 years | U-M MIDAS PODS | C. Gillies | ||
| Novel Systolic Target Assessment Tool (STAT) for TBI, Prototyping and Refinement | $113,710 | 7/1/19 | 1 year | Massey TBI Grand Challenge | K. Ward, H. Tiba, D. Hackenson | ||
| Evaluating Non-invasive Mitochondrial Modulation in a Translational Model of TBI | $182,841 | 7/1/19 | 1 year | Massey TBI Grand Challenge | T. Sanderson, J. Wider, H. Tiba, K. Ward | ||
| Neuroprotection with Intranasal Insulin after TBI | $99,839 | 7/1/19 | 1 year | Massey TBI Grand Challenge | T. Sanderson, T. Jinka, G. Wakam | ||
| Valproic Acid Treatment for Varying Severities of TBI and Optimizing Valproic Acid Administration in Isolated TBI | $220,212 | 7/1/19 | 1 year | Massey TBI Grand Challenge | B. Biesterveld, H. Alam, M. Pai | ||
| A POC Microfluidic Device for High Frequency and Real-Time Measurement of Biofluid Biomarkers (Continuation of 2017 grant) | $107,996 | 7/1/19 | 1 year | Massey TBI Grand Challenge | M. Burns, F. Korley | Emerging Product | |
| Development of an Augmented Reality Based Education Tool for Families of TBI Victims (AR/VR) | $130,000 | 7/1/19 | 1 year | Massey TBI Grand Challenge | C. Brake, C. Williamson, K. Ward | Licensed | |
| Michigan Resuscitation Innovation and Science Enterprise (M-RISE) | $4,196,385 | 5/24/19 | 4 years | American Heart Association | R. Neumar |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Real-time, Non-invasive Brain Metabolism | $118,666 | 8/1/18 | 1 year | Massey TBI Grand Challenge | O. Kripfgans, V. Rajajee, H. Tiba | ||
| A Novel Tensor Similarity Score for the Classification of Cardiac Index | $80,000 | 7/25/18 | 1 year | U-M Precision Health | N. Tokcan | ||
| Diagnostic tool for coagulation abnormalities in Traumatic Brain Injury | $120,000 | 7/1/18 | 1 year | Massey TBI Grand Challenge | M. Burns, K. Ward | ||
| Mesenchymal Stem Cell Derived-Exosomes as a Neuroprotective and Neurorestorative Treatment Strategy for Traumatic Brain Injury | $110,570 | 7/1/18 | 1 year | Massey TBI Grand Challenge | A. Williams, H. Alam, B. Buller | Licensed | |
| Noninvasive modulation of mitochondria for the treatment of secondary phase traumatic brain injury | $99,686 | 7/1/18 | 1 year | Massey TBI Grand Challenge | |||
| A point-of-care microfluidic device for high frequency and real-time measurement of biofluid biomarkers (Continuation of 2017 grant) | $115,800 | $107,996 | 7/1/18 | 1 year | Massey TBI Grand Challenge | F. Korley | Emerging |
| Intracranial pressure monitor enhancement for cerebral hemodynamic monitoring | $104,433 | 7/1/18 | 1 year | Massey TBI Grand Challenge | K. Oldham, H. Tiba, C. Williamson, K. Ward | ||
| Bridging the Translational Gap in the Acute Respiratory Distress Syndrome with an Innovative Porcine Model | $100,000 | 5/25/18 | 1 year | U-M MICHR | K. Stringer |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| ECPR after Prolonged Cardiac Arrest: Targeting Mechanisms of No-Reflow | $3,894,128 | 7/1/17 | 5 years | NIH | R. Neumar, R. Bartlett | ||
| Systolic target assessment tool (STAT) for TBI management | $73,975 | 7/1/17 | 1 year | Massey TBI Grand Challenge | D. Hackenson | ||
| Identification of monitoring biomarkers for optimizing TBI studies | $94,693 | 7/1/17 | 1 year | Massey TBI Grand Challenge | F. Korley | ||
| DEVD: Advanced digital extraventricular drain with data analytics integration (Continuation of 2016 grant) | $81,804 | 7/1/17 | 1 year | Massey TBI Grand Challenge | R. Daniels | Emerging Product | |
| Barreleye©:A decision support tool for TBI care (Continuation of2015 grant) | $83,489 | $17,108,507 | 7/1/17 | 1 year | Massey TBI Grand Challenge | A. Belle | Licensed |
| Automated extracranial internal carotid artery ultrasound sensor | $115,695 | 7/1/17 | 1 year | Massey TBI Grand Challenge | C. Hsu, G. Kruger | ||
| Cerebrovascular blood volume assessment using brain bioimpedance (TOBI) | $130,565 | $1,481,538 | 7/1/17 | 1 year | Massey TBI Grand Challenge | H. Tiba | Licensed |
| Increased Neuroprotection Using Novel Drug Therapies | $75,711 | 7/1/17 | 1 year | Massey TBI Grand Challenge | O. Ahmed | ||
| Multimodal Integrative Platform for Continuous Monitoring during Postoperative Care in Cardiac Patients | $2,202,161 | 5/1/17 | 3 years | Department of Defense | K. Najarian | ||
| Gastroesophageal Resuscitative Occlusion of the Aorta (GROA) | $2,999,802 | 2/1/17 | 3 years | Department of Defense | K. Ward, H. Tiba | Licensed | |
| Novel Noninvasive Methods of Intracranial Pressure and Cerebrovascular Autoregulation Assessment: Seeing the Brain through the Eyes (TOBI) | $1,481,538 | 1/1/17 | 3 years | Department of Defense | H. Tiba | Licensed |
| Project Title | Initial Funding | Follow-On Funding | Funding Start | Funding Period | Initial Funding Source | Principal Investigators | Product Phase |
| Career Development Program in Emergency Care Research (K12) | $1,914,017 | 9/27/16 | 5 years | NIH | R. Neumar, D. Pinsky | ||
| Feasibility Study for Developing an In-Vehicle Emergency Medical Condition | $162,800 | 7/15/16 | 1 year | Toyota | K. Najarian | Licensed | |
| Development of intravenous Imatinib targeting PDGF signaling TBI | $132,460 | 7/1/16 | 1 year | Massey TBI Grand Challenge | D. Lawrence | ||
| Using Advanced Genomic and Proteomic Technology to Ensure Valproic Acid's Success as an Early Treatment of Traumatic Brain Injury | $98,404 | 7/1/16 | 1 year | Massey TBI Grand Challenge | H. Alam | ||
| Digital Extra-Ventricular Drain (EVD) with Integrated Intracranial Pressure (ICP) Monitor and Cerebral Spinal Fluid (CSF) Flow Monitor/Pressure Regulator | $79,725 | $81,804 | 7/1/16 | 1 year | Massey TBI Grand Challenge | R. Daniels | Emerging Product |
| Automated Detection and Measurement of Subdural Hematoma Imaging Characteristics Following Traumatic Brain Injury | $75,611 | 7/1/16 | 1 year | Massey TBI Grand Challenge | C. Williamson | ||
| Quantitative Pupillometry for the Acute Detection and Prognosis of Traumatic Brain Injury | $113,800 | 7/1/16 | 1 year | Massey TBI Grand Challenge | W. Meurer | ||
| Real-Time Hemodynamic Monitoring System | $108,507 | $17,083,409 | 7/1/15 | 1 year | Massey TBI Grand Challenge | A. Belle | Licensed |
| Automated Brain Image Analysis & Decision Support System | $85,236 | 7/1/15 | 1 year | Massey TBI Grand Challenge | K.Najarian | ||
| Improving TBI-Induced Synaptic Changes | $70,000 | 7/1/15 | 1 year | Massey TBI Grand Challenge | L. Satin | ||
| Cerebral Hematoma in Traumatic Brain Injury | $85,000 | 7/1/15 | 1 year | Massey TBI Grand Challenge | R. Keep, G. Xi, Y. Hua | ||
| Protecting Injured Brain Cells with Imatinib | $80,000 | 7/1/15 | 1 year | Massey TBI Grand Challenge | D. Lawrance | ||
| Non-Invasive Assessment of Intracranial Pressure | $106,262 | $1,481,538 | 7/1/15 | 1 year | Massey TBI Grand Challenge | K. Ward, H. Tiba | Licensed |
| Early Administration of Plasma & Valproic Acid | $115,000 | 7/1/15 | 1 year | Massey TBI Grand Challenge | H. Alam | ||
| Computer-Aided Decision Support System for Pelvic and Abdominal Injuries | $199,993 | 4/1/15 | 1.5 years | NSF | K. Najarian | ||
| Chiroplasmic Nanorod-PCR (NR-PCR) for Rapid Determination of Bacteremia and Antibiotic Resistance in Sepsis | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | S. VanEpps, N. Kotov | ||
| Development of a Sepsis Point-of-Care (POC) Platform Utilizing Redox Measurements with Integrated Protein Markers of Sepsis as a Bedside Biomarker for Sepsis, Severity of Septic Shock, and as a Gauge for Resuscitation Endpoints | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | R. Daniels, S. Takayama, M. Meyerhoff | ||
| Real-Time Ultrasound Local Lung Ventilation Measurement | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | J. Rubin, C. Deng | ||
| Sepsis Endotheliopathy Assessment Panel | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | R. Daniels, S. Fan | ||
| Immunotherapy and Immuno-phenotyping for Treatment of Sepsis | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | J. Nemzek, J. Fu, J. Moon | ||
| Non-Invasive Portable System for Continuous Monitoring of Sepsis | $50,000 | 7/1/14 | 1 year | MCIRCC Sepsis Grand Challenge | K. Najarian, K. Oldham |
