Professor of Computational Medicine and Bioinformatics
Professor of Internal Medicine
[email protected]
Available to mentor
Yuanfang Guan, PhD
Professor
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Ph.D., Molecular BiologyPrinceton University, Princeton, NJ, 2010
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BS, BiologyThe University of Hong Kong, Hong Kong, 2005
The Guan lab's research focus is machine learning in biology and medical fields.
Guan Lab
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Deng K, Schwendeman PS, Guan Y. Adv Sci (Weinh), 2024 Apr; 11 (15): e2305626Journal ArticlePredicting Single Neuron Responses of the Primary Visual Cortex with Deep Learning Model.
DOI:10.1002/advs.202305626 PMID: 38350735 -
Schuster KH, Zalon AJ, DiFranco DM, Putka AF, Stec NR, Jarrah SI, Naeem A, Haque Z, Zhang H, Guan Y, McLoughlin HS. Mol Ther, 2024 May 1; 32 (5): 1359 - 1372.Journal ArticleASOs are an effective treatment for disease-associated oligodendrocyte signatures in premanifest and symptomatic SCA3 mice.
DOI:10.1016/j.ymthe.2024.02.033 PMID: 38429929 -
Dang X, Li W, Zou J, Cong B, Guan Y. iScience, 2024 Feb 16; 27 (2): 108626Journal ArticleAssessing the impact of body location on the accuracy of detecting daily activities with accelerometer data.
DOI:10.1016/j.isci.2023.108626 PMID: 38318391 -
Lin C-X, Guan Y, Li H-D. Curr Opin Struct Biol, 2024 Feb; 84: 102747Journal ArticleArtificial intelligence approaches for molecular representation in drug response prediction.
DOI:10.1016/j.sbi.2023.102747 PMID: 38091924 -
Rafi AM, Nogina D, Penzar D, Lee D, Lee D, Kim N, Kim S, Kim D, Shin Y, Kwak I-Y, Meshcheryakov G, Lando A, Zinkevich A, Kim B-C, Lee J, Kang T, Vaishnav ED, Yadollahpour P, Random Promoter DREAM Challenge Consortium , Kim S, Albrecht J, Regev A, Gong W, Kulakovskiy IV, Meyer P, de Boer CG. Nat Biotechnol, 2024 Oct 11;Journal ArticleA community effort to optimize sequence-based deep learning models of gene regulation.
DOI:10.1038/s41587-024-02414-w PMID: 39394483 -
Salcedo A, Tarabichi M, Buchanan A, Espiritu SMG, Zhang H, Zhu K, Ou Yang T-H, Leshchiner I, Anastassiou D, Guan Y, Jang GH, Mootor MFE, Haase K, Deshwar AG, Zou W, Umar I, Dentro S, Wintersinger JA, Chiotti K, Demeulemeester J, Jolly C, Sycza L, Ko M, PCAWG Evolution and Heterogeneity Working Group , SMC-Het Participants , Wedge DC, Morris QD, Ellrott K, Van Loo P, Boutros PC. Nat Biotechnol, 2024 Jun 11;Journal ArticleCrowd-sourced benchmarking of single-sample tumor subclonal reconstruction.
DOI:10.1038/s41587-024-02250-y PMID: 38862616 -
Wang Y, Myers G, Yu L, Deng K, Balbin-Cuesta G, Singh SA, Guan Y, Khoriaty R, Engel JD. Blood, 2024 Oct 11;Journal ArticleTR4 and BCL11A Repress γ-globin Transcription via Independent Mechanisms.
DOI:10.1182/blood.2024024599 PMID: 39393056 -
Zhang H, Wang Z, Nan Y, Zagidullin B, Yi D, Tang J, Guan Y. Commun Biol, 2023 Apr 11; 6 (1): 397Journal ArticleHarmonizing across datasets to improve the transferability of drug combination prediction.
DOI:10.1038/s42003-023-04783-5 PMID: 37041243
Department News
Five DCMB faculty were promoted. They are Yuanfang Guan, Ph.D., Jie Liu, Ph.D., Ryan Mills, Ph.D., Stephen C.J. Parker, Ph.D., and Arvind Rao, Ph.D. Congratulations!
