Key Papers
How we got here, and where we’re going next...
Investigations of EBV infection, pathogenesis, and associated diseases viewed through the lens of single-cell and spatial virology
Chadburn A, Hernandez MMA, Dai JY, Harrison M, Reinoso-Vizcaino NM, Barry AP, Hocke E, Abramson K, Jain V, Chan C, Cesarman E, Luftig MA, SoRelle ED. HIV-associated non-Hodgkin lymphoma tumor-microenvironment axes differ by EBV status across cellular origins. [in preparation]
SoRelle ED, Luftig MA. Multiple sclerosis and infection: history, EBV, and the search for mechanism. Microbiology & Molecular Biology Reviews. [invited review, accepted]
SoRelle ED*, Haynes LE*, Willard KA, Chang B, Ch’ng J, Christofk H, Luftig MA. Epstein-Barr virus reactivation induces divergent abortive, reprogrammed, and host shutoff states by lytic progression. PLoS Pathogens. 2024 20(10): e1012341. doi.org/10.1371/journal.ppat.1012341.
Dai J, SoRelle ED, Heckenberg E, Song L, Cable JM, Crawford GE, Luftig MA. Epstein-Barr virus induces germinal center light zone chromatin architecture and promotes survival through enhancer looping at the BCL2A1 locus. mBio. 2024 15(1): e02444-23. doi:10.1128/mbio.02444-23. PMCID: PMC10790771.
SoRelle ED, Reinoso-Vizcaino NM, Dai J, Barry AP, Chan C, Luftig MA. Epstein-Barr virus evades restrictive host chromatin closure by subverting B cell activation and germinal center regulatory loci. Cell Reports. 2023. 42(8): 112958. doi: 10.1016/j.celrep.2023.112958. PMCID: PMC10559315.
SoRelle ED, Haukenfrers E, Jain V, Abramson K, Hocke E, Cooney LA, Harris KM, Zamvil SS, Gregory SG, Luftig MA. An EBV-associated atypical B cell signature in clinically isolated syndrome is implicated in progression of multiple sclerosis. medRxiv. March 1st, 2023. 23286433. doi: 10.1101/2023.02.26.23286433.
SoRelle ED*, Reinoso-Vizcaino NM*, Horn GQ, Luftig MA. Epstein-Barr virus perpetuates B cell germinal center dynamics and generation of autoimmune-associated phenotypes in vitro. Frontiers in Immunology. 2022 13: 1001145. doi: 10.3389/fimmu.2022.1001145. PMCID: PMC9554744.
SoRelle ED, Dai J, Reinoso-Vizcaino NM, Barry AP, Chan C, Luftig MA. Time-resolved transcriptomes reveal diverse B cell fate trajectories in the early response to Epstein-Barr Virus infection. Cell Reports. 2022. 40(9): 111286. doi: 10.1016/j.celrep.2022.111286. PMCID: PMC9879279.
Yellen BB, Zawitsowski JS, Czech EA, Sanford CI, SoRelle ED, Luftig MA, Forbes ZG, Wood KC, Hammerbacher J. Massively parallel quantification of phenotypic heterogeneity in single cell drug responses. Science Advances 2021 Sep 17;7(38):eabf9840. PMCID: PMC8448449.
SoRelle ED, Dai J, Bonglack EN, Heckenberg EM, Zhou JY, Giamberardino SN, Bailey JA, Gregory SG, Chan C, Luftig, MA. Single-cell RNA-seq reveals transcriptomic heterogeneity mediated by host-pathogen dynamics in lymphoblastoid cell lines. eLife. 2021; e62586. doi: 10.7554/eLife.62586. PMCID: PMC7867410.
