University of Michigan
Anne B. Young Collegiate Professor, Department of Neurology
Michigan ADRC, Research Education Component Lead
[email protected]
Scientific expertise
Movement Disorders; Neurodegeneration Clinical Research
Methods or instrumentation
PET Imaging
Training
Participant Characterization
Grant application reviews
Neurodegeneration research
University of Michigan
Assistant Professor, Department of Epidemiology, School of Public Health
Michigan ADRC, Data and Statistical Core Lead
[email protected]
https://sites.google.com/umich.edu/bakulskiresearch/home
Scientific expertise
Environmental chemical and genetic risk factors for neurological disorders using epidemiology and toxicology methods.
Core resources
Contact information for study recruitment, data for secondary analyses, database design/automation, statistical consultation for grant/manuscript, collaboration for analyses for grant/manuscript
Methods or instrumentation
Data preprocessing and analysis for genetics, RNA expression, epigenetics, and exposomics
Training
I teach three regular classes in programming in R statistical software, epigenomics data QC and analyses, and pathophysiology
Grant application reviews
Epidemiology, toxicology, genetics, environmental exposures
University of Michigan
Angela Dobson Welch and Lyndon Welch Research Professor of Neurology
Director, Michigan Brain Bank
Michigan ADRC, Leaders Initiative, Neuropathology Core
[email protected]
www.barmadalab.com
Scientific expertise
We focus on disease mechanisms and therapeutic strategies in amyotrophic lateral sclerosis and frontotemporal dementia. Our objective is to use these models to test and identify effective new therapeutics; and define the pathways culminating in neurodegeneration in these disorders.
Animal models
Primary neurons isolated from rodents (rattus norvegicus, mus musculus) or human stem cell-derived neurons from individuals with sporadic and familial disease Lab resources: We are happy to help with imaging needs and disease modeling.
Other resources
Longitudinal microscopy, super-resolution microscopy
Methods or instrumentation
High content microscopy, super-resolution microscopy, longitudinal microscopy, directed differentiation of stem cells into neuronal subtypes
Training
Fluorescence microscopy, super-resolution microscopy, human neuron differentiation from stem cells
Grant application reviews
Basic science of FTD/ALS, protein and RNA homeostasis, disease modeling
Michigan State University
Assistant Professor, Department of Neurology and Ophthalmology
Michigan ADRC, Leaders Initiative, Neuroimaging Core
[email protected]
Scientific expertise
My expertise is in structural and diffusion MRI in the contexts of cognitive aging, lifespan development, and neurodegenerative disease. In addition to a host of methods for MRI processing, my work uses a variety of approaches for statistical analysis including structural equation modeling, mixed effects models, partial least squares, and path analysis.
Methods or instrumentation
MRI processing methods (e.g., ANTs, ASHS, FSL, Freesurfer, MRtrix, SPM); high dimensional analysis methods (e.g., clustering, mixed effects models); manual and automated brain segmentation methods; advanced diffusion MRI processing (e.g., MRtrix, NODDI, DKI)
Training
My lab has training resources for basic image processing, and we can offer consultation on image segmentation and diffusion MRI methods.
Grant application reviews
Approach and significance of MRI methods, particularly for structural and diffusion MRI
Michigan State University
Research Assistant Professor, Department of Translation Science and Molecular Medicine
Michigan ADRC, Leaders Initiative, Biomarker Core
[email protected]
Scientific expertise
I study the role of tau protein in neurodegenerative disease using protein biochemistry, cultured cells, and animal models. Specifically, I look at the role of tau protein in dysregulation of axonal transport as a potential mechanism of tau's toxicity in disease.
Animal models
TauKO: a mouse line with the MAPT gene knocked out. hTau: a mouse line with human MAPT gene replacing mouse tau.
Methods or instrumentation
Primary neuron culture, confocal microscopy, electron microscopy
Grant application reviews
Tau protein, axonal transport
Michigan State University
Associate Professor of Translational Neuroscience
[email protected]
https://translationalscience.msu.edu/people/scott-counts.html
Scientific expertise
Cellular and molecular mechanisms of AD and VCID
Animal models
3 rat models: Tg344-19 AD (F344 rats carrying APPswe and PS1d9); Spontaneously hypertensive stroke-prone rats (SHRSPs, Wistar-Kyoto rats with naturally occurring vascular abnormalities); "Frankenrats" (Tg344-19 AD rats backcrossed onto SHRSPs as a model for VCID)
Methods or instrumentation
Laser capture microdissection (LCM)
Training
LCM; single neuron gene expression analysis; rat behavioral training; stereotactic surgery; all standard molecular, cell biological, histological, and biochemical assays
Grant application reviews
Anything dementia-related but specifically, anything that would be handled by CNN study section
Wayne State University
Associate Professor, Institute of Gerontology, Department of Psychology
Michigan ADRC, Leaders Initiative, Neuroimaging Core
[email protected]
connectlab.wayne.edu
Scientific expertise
Age and disease-related changes in cognition and brain structure and function. Early detection of atypical brain changes and identifying risk groups. Possible interventions to delay cognitive decline.
Methods or instrumentation
Functional and structural MRI; brain network connectivity
Training
General MRI data analyses; specific functional connectivity analyses
Grant application reviews
Cognitive and brain changes in aging and neurodegenerative disease; specifically, neuroimaging applications
Wayne State University
Associate Professor, Institute of Gerontology, Department of Psychology,
and Department of Psychiatry and Behavioral Neurosciences
Michigan ADRC, Leaders Initiative, Data Management and Statistical Core, Neuroimaging Core, Research Education Component
[email protected] | agingbrain.wayne.edu
Scientific expertise
Vascular and metabolic health factors that modify human brain aging and dementia risk. I use multimodal neuroimaging and blood biomarkers, actigraphy, neuropsychological assessment and health history to study longitudinal aging in community samples. Emphasis on pathways for hypertension-related risk for Alzheimer's disease and related dementia.
Methods or instrumentation
Multimodal MRI (structural T1, high-res hippocampal subfields, susceptibility weighted imaging, T2 FLAIR); actigraphy; (non-clinical) cognitive assessment
Training
Advanced statistics (multivariate methods, structural equation modeling, mixed models, reliability); MRI methods
University of Michigan
Edith Briskin Emerging Scholar
Postdoctoral Fellow, NeuroNetwork for Emerging Therapies
[email protected]
https://medicine.umich.edu/dept/mneuronet
Scientific expertise
Immuno-metabolic interactions in the CNS Animal models: C57BL6 high-fat diet-induced obesity and prediabetes
Methods or instrumentation
IHC (floating sections and confocal microscopy), Western blotting, Cognitive testing in mice
Training
IHC (floating sections and confocal microscopy), Western blotting, Cognitive testing in mice
Grant application reviews
Basic review of scientific content and minor editing of language/structure
University of Michigan
Assistant Professor, Neuropathology in the Department of Pathology
Michigan ADRC, Leaders Initiative, Neuropathology Core
Scientific expertise
Clinical neuropathology (surgical, muscle/nerve, dementia brain autopsy diagnosis), PhD in biochemistry/glycoprotein folding, experience in mouse work
Methods or instrumentation
Whole slide scanning, immunohistochemistry through the U-M pathology department
Training
Neuropathology, mouse necropsy
Grant application reviews
Neuropathology, mouse work
University of Michigan
Professor of Psychology, Departments of Psychiatry, Neurology, Psychology
Chief Psychologist, Department of Psychiatry
Senior Director, Mary A. Rackham Institute
Michigan ADRC, Associate Director
[email protected]
Scientific expertise
The earliest appearance of cognitive and motor features in healthy aging and dementia. Nonpharmacological to cognitive loss in aging and medical illness.
Other resources
Driving simulators
Methods or instrumentation
Computer-based assessment, EEG methodologies
Training
Computer-based assessment and remediation of cognitive, motor, and behavioral features in medical illness and dementia
Grant application reviews
See previous
Michigan State University
Professor of Translational Neuroscience
[email protected]
https://translationalscience.msu.edu/research-groups/gordon-lab.html
Scientific expertise
I am especially interested in the role of innate immunity in aging and neurodegenerative disease. Increasingly, my research focuses on developing novel therapeutics to modulate innate immunity, including small molecule agents, vaccines, gene therapy and biologics, using transgenic mouse models with Alzheimer-like pathology.
Animal models
APP+PS1 transgenic mice = age-dependent accumulation of amyloid deposits, cognitive deficits and innate immune activation; rTg4510 = transgenic mice overexpressing 4R tau, with age-dependent tau phosphorylation, aggregation and deposition leading to cognitive impairments; PS-19= similar to Tg4510 but less aggressive.
Methods or instrumentation
Bench-top cell sorter, mouse behavior facility, digital slide scanner and computer-assisted image analysis
Grant application reviews
Innate immune activation, mouse models, innate immunity, glial activation
University of Michigan
Stanley Berent, PhD, Collegiate Professor of Psychology
Michigan ADRC, Clinical Core Lead
[email protected]
https://hampstead.lab.medicine.umich.edu/home
Scientific expertise
I focus on the early detection of, and non-pharmacologic treatment for, cognitive deficits arising from neurologic injury and disease.
Core resources
UM-MAP data set
Methods or instrumentation
TMS, tES, fNIRS, s/fMRI, neuropsych measures, cognition-oriented treatments
Training
TMS, tES, fNIRS, s/fMRI, neuropsych measures, cognition-oriented treatments
Grant application reviews
Areas related to neuromodulation, neuroimaging, non-pharmacologic interventions, and diagnosis
University of Michigan
Richard D. and Katherine M. O’Connor Research Professor of Neurology
Michigan ADRC, Clinical Core Co-Lead
[email protected]
Scientific expertise
Clinical research pertinent to the diagnosis/management of dementia, including clinical trials in the prevention and treatment of Alzheimer's disease
Methods or instrumentation
Clinical trial methodology
Training
Clinical trial methodology
Grant application reviews
Clinical trials in dementia prevention/treatment
University of Michigan
Research Professor, Department of Biomedical Engineering and Functional MRI Laboratory
Co-Director, Animal MRI Facility
[email protected] http://fmri.research.umich.edu/about/faculty/hernandez.php
Scientific expertise
MRI, brain blood flow, non-invasive neuromodulation
Methods or instrumentation
MRI
Training
MRI, signal processing, mathematical modeling
Grant application reviews
MRI, signal processing, mathematical modeling
Michigan State University
College of Human Medicine, Director of Research Initiatives
Michigan Dementia Coalition
Michigan ADRC, Outreach, Recruitment and Engagement Core Investigator
[email protected]
Scientific expertise
Health Services Research and Implementation Science, Chronic Disease Self-Management Program Implementation and Evaluation
Training
Translational research phases T3 and T4
Grant application reviews
Translational research phases T3 and T4
Michigan State University
Associate Professor of Translational Neuroscience
Michigan ADRC, Biomarker Core Co-Lead
[email protected]
https://translationalscience.msu.edu/research-groups/kanaan-lab.html
Scientific expertise
Molecular mechanisms of disease with a focus on Alzheimer's disease and other tauopathies, as well as tau protein biology and pathobiology
Animal models
Wild-type C57 mice; PS19 transgenic mice: mice harboring P301S mutant tau; Human tau knockin mice (Saido model): endogenous mouse tau gene was replaced with human tau gene and mice express all 6 human tau isoforms; Tau knockout mice: endogenous mouse tau gene was removed
Core resources
Blood (or other biological fluid) biomarker assessments via SIMOA immunoassays and/or mass spectrometry
Methods or instrumentation
Microscopy (TEM, confocal), Recombinant protein, monoclonal antibody production, biomarkers (SIMOA immunoassays), histology, biochemical assays, molecular biology assays, cell culture (including primary neurons), rodent models of tauopathy
Training
Any of the previous
Grant application reviews
Grants on AD, tauopathy, tau, aging, PD
University of Michigan
Professor of Radiology
[email protected]
Scientific expertise
Research interests center around the quantitative aspects of positron emission tomography (PET). Specific research areas include the development and implementation of tracer kinetic models for new and existing positron-labeled radiotracers. Has extensive experience in multi-center trials involving PET imaging of amyloid and tau.
Methods or instrumentation
PET Scanning
Wayne State University
Assistant Professor, Institute of Gerontology and Department of Psychology
Michigan ADRC, Leaders Initiative, Clinical Core
[email protected]
Scientific expertise
Family caregiving for individuals living with dementia
Methods or instrumentation
Mixed-methods, qualitative and quantitative data analysis
Grant application reviews
Social and behavioral science applications surrounding dementia
Wayne State University
Distinguished University Service Professor of Psychology
Director of the Institute of Gerontology and Merrill Palmer Skillman Institute
Michigan ADRC, REC Co-Lead
[email protected]
https://iog.wayne.edu/profile/aa2275
Scientific expertise
Clinical geropsychology and geriatric neuropsychology; Financial decision making and neurocognitive decline; the intersection of declining cognition, financial management and financial exploitation.
Core resources
REC provides several opportunities including developmental funds
Methods or instrumentation
Interviews, cognitive assessment
Training
Community-engaged research, financial capacity measurement; Engaging with African American communities to enhance research participation
Grant application reviews
Behavioral science grants--both basic and intervention; Community-based work in behavioral sciences
University of Michigan
Gerald Abrams Collegiate Professor of Pathology
Michigan ADRC, Neuropathology Core Lead
[email protected]
https://www.pathology.med.umich.edu/andrew-p-lieberman-lab
Scientific expertise
Neuropathology, cellular and mouse models of neurodegeneration, polyglutamine and lysosomal disorders
Animal models
AR113Q; Npc1 -/-; Npc1 flox; human NPC1 I1061T
Methods or instrumentation
Molecular biology, biochemistry, histology
Training
Analysis of neuropathology
Grant application reviews
Mechanisms of neurodegeneration
Michigan State University
Professor, Department of Translational Neuroscience
Michigan ADRC, Biomarker Core Co-Lead
[email protected]
Scientific expertise
Neurochemistry of memory. Mouse models of amyloidosis and tauopathy. Immunotherapy and gene therapy. CSF and Blood fluid biomarkers in AD
Animal models
APP+PS1 model of amyloidosis. PS19 model of tauopathy. Aged C57 mice.
Core resources
Access to SIMOA assays
Methods or instrumentation
Digital scanning microscopy, SIMOA protein measurement at fg/ml levels
Training
Quantitative microscopy
Grant application reviews
Animal models, drug development, fluid biomarkers
University of Michigan
Ann and Robert H. Lurie Professor of Biomedical Engineering
Professor, Department of Radiology
Co-Director, fMRI Center
Michigan ADRC, Neuroimaging Core Lead
[email protected]
https://nollresearch.engin.umich.edu/
Scientific expertise
Research is focused on the data acquisition and processing for imaging brain function using magnetic resonance imaging (functional MRI or fMRI). Projects include the development of image acquisition and reconstruction techniques, post-processing and analysis methods, methods for elimination of movement and other artifacts, and the development of neuroimaging biomarkers for disease.
Core resources
Access to neuroimaging data for MADRC cohorts, consulting on the design of imaging components and imaging biomarkers, consulting on image analysis
Methods or instrumentation
3T MRI, Functional and Anatomical MRI
Training
MRI Physics, MRI protocols, fMRI experimental design
Grant application reviews
Imaging components
University of Michigan
Lucile Groff Professor of Neurology for Alzheimer’s Disease and Related Dementias
Interim Co-Director, Michigan Neuroscience Institute
Michigan ADRC, Director and Principal Investigator
[email protected]
Scientific expertise
Mechanisms of age-related neurodegenerative diseases Animal models: multiple polyglutamien mouses models, esp. SCa3; P301S Tau tg ; A53T synuclein tg; WT-UBQLN2 and P506T-UBQLN2 tgtg
Methods or instrumentation
Basic molecular and cell biological methods
Training
Basic molecular and cell biological methods
Grant application reviews
Mechanisms of neurodegenerative diseases
University of Michigan
Technical Director and Research Scientist Functional MRI Laboratory
[email protected]
fmri.research.umich.edu
Scientific expertise
MRI acquisition and data analysis
Core resources
The lab offers pilot grants for investigators to allow the collection of preliminary data
Methods or instrumentation
Human MRI scanners (3T)
Training
Our lab runs a yearly FMRI course
Grant application reviews
Imaging applications
University of Michigan
Assistant Professor, Department of Psychiatry
Michigan ADRC, Leaders Initiative, Outreach, Recruitment and Engagement Core
[email protected]
Scientific expertise
Family relationships and caregiving, chronic illness management, and complex care needs including dementia and multimorbidity
Methods or instrumentation
Daily diary and ecological momentary assessment, salivary biomarkers, dyadic
data
Grant application reviews
Caregiving, chronic illness management, dyadic data
University of Michigan
Assistant Professor, Department of Psychiatry
Michigan ADRC, Leaders Initiative, Clinical Core
[email protected]
Program website
https://hampstead.lab.medicine.umich.edu/home
Scientific expertise
Neuropsychology, cognitive aging, biomarker disclosure
Methods or instrumentation
Neuropsychological testing, PET imaging, feedback, biomarker disclosure, mixed methods
Training
Cognitive testing, test development and validation, psychometrics
Grant application reviews
Neuropsychology, cognitive aging, caregiving, TBI, Alzheimer's disease and related dementias
University of Michigan
Professor, Health Behavior and Health Education
Michigan ADRC, Outreach, Recruitment and Engagement Core Lead
[email protected]
https://robertsresearch.org/
Scientific expertise
Health communication; bioethics; dementia education; health psychology, especially as applied to genetic testing
Core resources
We can help assist studies actively trying to recruit participants; we can offer speaking opportunities/feature articles on our website/newsletter to promote the visibility of their work
Methods or instrumentation
Social and behavioral health surveys
Training
Social/behavioral interventions/surveys; RCR / ELSI
Grant application reviews
Grants addressing psychosocial issues posed by Alzheimer's disease
University of Michigan
Assistant Professor, Department of Systems, Populations and Leadership, School of Nursing
Michigan ADRC, Leaders Initiative, Outreach Recruitment and Engagement Core
[email protected]
https://nursing.umich.edu/faculty-staff/faculty/sheria-g-robinson-lane
Scientific expertise
My work examines the personal, familial, and structural adaptations necessary for diverse older adults to age in place with cognitive and/ or physical disabilities. This work is evaluated through a health equity lens.
Methods or instrumentation
Content analysis, ethnography, mixed-methods study design
Grant application reviews
Pain and symptom management, informal caregiving, long-term care services, community-based participatory research, anti-racism
University of Michigan
Associate Professor of Neurology
[email protected]
Scientific expertise
MRI measures of neurodegeneration and disease progression.
Methods or instrumentation
MRI, morphometrics, fMRI, MRS and diffusion MR
Training
Post-processing of MR data
Grant application reviews
Imaging research
University of Michigan
Albert M. Mattocks Professor of Pharmaceutical Sciences and Chemical Engineering
[email protected]
https://tessier.lab.medicine.umich.edu/
Scientific expertise
My lab focuses on therapeutic antibody discovery, engineering, and optimization of affinity and specificity. We also work on the delivery of antibodies to the brain using bispecific antibodies.
Animal models
Wild type and PS19 (tau) mice
Methods or instrumentation
Mammalian protein production (suspension HEK 293 and CHO), immunization and in vitro antibody library generation, single B-cell sorting for antibody generation, flow cytometry and FACS
Training
Mammalian antibody production, antibody discovery and engineering
Grant application reviews
Therapeutic antibodies
Michigan State University
Associate Professor, Department of Translational Neuroscience
Michigan Center for Contextual Factors in Alzheimer’s Disease, Recruitment Core Co-Lead
Michigan ADRC, REC Co-Lead
[email protected]
https://translationalscience.msu.edu/research-groups/vega-lab.html
Scientific expertise
Proteome changes associated with the accumulation of pathological tau. Identification of biomarkers in tissue and biofluids. Health disparities associated with ADRD.
Animal models
JNPL3 - expresses htauP301L under the prion promoter (SW background as developed at Mayo Clinic JAX by Mike Hutton and Jada Lewis).
Other resources
At the Integrated Mass Spectrometry Unit, we provide proteomics services.
https://translationalscience.msu.edu/resources/proteomics.html
Methods or instrumentation
Mass spectrometry-based proteomics for the identification and quantification of proteins and PTMs
Training
Proteomics
Grant application reviews
Projects related to tauopathies that involve molecular and biochemical approaches. Also, projects that propose interventions related to ADRD in underserved and underrepresented groups
